Importance of Grazing Management in Improving Water Use Efficiency of Tropical Forage Grasses

The growing number of extreme weather events has created the need to identify tropical forage grasses with greater water use efficiency (WUE) to cope with water-limited conditions. WUE can be defined as the ratio of forage biomass produced per unit of water used. However, WUE is a dynamic ratio that changes according to environmental gradients (e.g., water or nutrient availability) or ontogenetic drift (e.g., changes in root to shoot biomass allocation across phenological stages). Furthermore, genetic improvement leading to greater WUE is likely to result in smaller plants that produce less than the required forage biomass to sustain good animal performance. Bearing that in mind, other alternatives for improving WUE must be taken into consideration. Grazing management is one among such alternatives. Results from a greenhouse experiment conducted with a number of forage grasses (Cenchrus ciliaris, Chloris gayana, Megathyrsus maximus, Urochloa spp.) at the Alliance of Bioversity-CIAT showed that different grazing intensities lead to various WUEs. Improved WUE values in grasses can be achieved through grazing management if it moderates the process of evapotranspiration by 1) reducing leaf area per plant; and 2) maintaining soil cover from pasture growth and productivity. Our results suggest that WUE in pastures planted with tropical forage grasses can be enhanced through moderate rotational grazing

BIOPSIA DE ENCIA EN EL DIAGNOSTICO DE LA MICROANGIOPATIA DIABETICA

A study was made of gingival biopsies perfomed in 42 patients, 24 of the patients. Were diabetics and 18 were non diabeties used as controls. Capillary lesions were found in all diabetic patients. These lesions varied from a minimal thickening of the basement membrane. This thickening was P.A.S. positive. In 90% of the diabetic patients a thickening of the nodular type in the walls of the thickened capillaries and too were fonud a series of pictures of transition between the diffuse, more or less irregular thickening and the appearance of these modular images was noticed; these lesions showed an irregular eosinophilia. The stains used showed that these nodular formations react in the same way as the nodular lesions of the diabetic glomerulies. The authours consider these gingival lesions another manifestation of the generalized vascular damage which is thought to be to the same pathogenic mechanism and to be another manifestation of diabetic microangyopathy.Se hizo un estudio de biópsia gíngivales realizadas en 42 pacientes, 24 de los pacientes diabéticos y 18 no lo fueron sino utilizados como controles. Se encontraron lesiones capilares en todos los pacientes diabéticos. Estas lesiones variaron desde un espesor mínimo de la membrana basal profunda. Este espesor fue PAS positivo. En el 90% de los pacientes diabéticos se encontró una espesura de tipo nodular (acumulación de glicoproteinas) en las paredes de los capilares, asi como también se encontraron una serie de cuadros de transición entre los difusos; se notó más o menos una espesura irregular y una apariencia de éstas imágenes irregulares nodulares. Estas lesiones mostraron eosinofilia irregular. Los tintes que se utilizaron mostraban que estas formaciones nodulares de los glomérulas diabéticos. Los autores consideran que estas lesiones gingivales como otra manifestación del daño vascular generalizado que probablemente ocurre en diabéticos y que se presume que sea el mismo mecanismo patogénico y también otra manifestación de la microangiopatia diabética

Beyond Prejudice as Simple Antipathy: Hostile and Benevolent Sexism Across Cultures

The authors argue that complementary hostile and benevolent componen:s of sexism exist ac ro.ss cultures. Male dominance creates hostile sexism (HS). but men's dependence on women fosters benevolent sexism (BS)-subjectively positive attitudes that put women on a pedestal but reinforce their subordination. Research with 15,000 men and women in 19 nations showed that (a) HS and BS are coherenl constructs th at correlate positively across nations, but (b) HS predicts the ascription of negative and BS the ascription of positive traits to women, (c) relative to men, women are more likely to reject HS than BS. especially when overall levels of sexism in a culture are high, and (d) national averages on BS and HS predict gender inequal ity across nations. These results challenge prevailing notions of prejudice as an antipathy in that BS (an affectionate, patronizing ideology) reflects inequality and is a cross-culturally pervasive complement to HS

Atezolizumab in locally advanced or metastatic urothelial cancer : a pooled analysis from the Spanish patients of the IMvigor 210 cohort 2 and 211 studies

Funding: This study was funded by Roche Farma, Spain.The studies IMvigor 210 cohort 2 and IMvigor211 evaluated the efficacy of atezolizumab in patients with locally advanced or metastatic urothelial cancer (mUC) upon progression to platinum-based chemotherapy worldwide. Yet, the real impact of this drug in specific geographical regions is unknown. We combined individual-level data from the 131 patients recruited in Spain from IMvigor210 cohort 2 and IMvigor211 in a pooled analysis. Efficacy and safety outcomes were assessed in the overall study population and according to PD-L1 expression on tumour-infiltrating immune cells. Full data were available for 127 patients; 74 (58%) received atezolizumab and 53 (42%) chemotherapy. Atezolizumab patients had a numerically superior median overall survival although not reaching statistical significance (9.2 months vs 7.7 months). No statistically significant differences between arms were observed in overall response rates (20.3% vs 37.0%) or progression-free survival (2.1 months vs 5.3 months). Nonetheless, median duration of response was superior for the immunotherapy arm (non-reached vs 6.4 months; p = 0.005). Additionally, among the responders, the 12-month survival rates seemed to favour atezolizumab (66.7% vs 19.9%). When efficacy was analyzed based on PD-L1 expression status, no significant differences were found. Treatment-related adverse events of any grade occurred more frequently in the chemotherapy arm [46/57 (81%) vs 44/74 (59%)]. Patients who achieved an objective response on atezolizumab presented a longer median duration of response and numerically superior 12 month survival rates when compared with chemotherapy responders along with a more favorable safety profile. PD-L1 expression did not discriminate patients who might benefit from atezolizumab

'Diverse mobilities': second-generation Greek-Germans engage with the homeland as children and as adults

This paper is about the children of Greek labour migrants in Germany. We focus on two life-stages of ‘return’ for this second generation: as young children brought to Greece on holidays or sent back for longer periods, and as young adults exercising an independent ‘return’ migration. We draw both on literature and on our own field interviews with 50 first- and second-generation Greek-Germans. We find the practise of sending young children back to Greece to have been surprisingly widespread yet little documented. Adult relocation to the parental homeland takes place for five reasons: (i) a ‘search for self’; (ii) attraction of the Greek way of life; (iii) the actualisation of the ‘family narrative of return’ by the second, rather than the first, generation; (iv) life-stage events such as going to university or marrying a Greek; (v) escape from a traumatic event or oppressive family situation. Yet the return often brings difficulties, disillusionment, identity reappraisal, and a re-evaluation of the German context

Marine collagen/apatite composite scaffolds envisaging hard tissue applications

The high prevalence of bone defects has become a worldwide problem. Despite the significant amount of research on the subject, the available therapeutic solutions lack efficiency.  Autografts, the most common used approaches to treat bone defects have limitations such as donor site morbidity, pain and lack of donor site. Marine resources emerge as an attractive alternative to extract bioactive compounds for further use in bone tissue engineering approaches. On one hand they can be isolated from by-products, at low costs, creating value from products that are considered waste for the fish transformation industry. One the other hand, religious constraints will be avoided. We isolated two marine origin materials, collagen from shark skin (Prionace glauca) and calcium phosphates from teeth of two different shark species (Prionace glauca and Isurus oxyrinchus), and further proposed to mix them to produce 3D composite structures for hard tissue applications. Two crosslinking agents, EDC/NHS and HMDI, were tested to enhance scaffoldsâ properties, with EDC/NHS resulting in better properties. The characterization of the structures showed that the developed composites could support attachment and proliferation of osteoblast-like cells. A promising scaffold for the engineering of bone tissue is thus proposed, based on a strategy of marine by-products valorisation.This work was funded by INTERREG under the POCTEP Project 0687_NOVOMAR_1_P and the Atlantic Area Transnational Cooperation Programme Project MARMED (2011-1/164), as well as by European Union FP7 under the project POLARIS (REGPOT-CT2012-316331).info:eu-repo/semantics/publishedVersio

Compósitos de colagénio/apatite de origem marinha para aplicação em engenharia de tecidos mineralizados

Devido ao aumento de lesões associadas ao envelhecimento da população, a regeneração do tecido ósseo tem sido alvo de estudo. Apesar da vasta investigação neste sentido, os auto-enxertos continuam a prevalecer como tratamento de primeira linha, apesar das suas limitações. A extração de compostos de recursos marinhos para uso em abordagens de engenharia de tecidos emerge como uma alternativa promissora para regeneração de lesões ósseas. Neste capítulo apresenta-se um biomaterial promissor para aplicação em engenharia de tecidos duros tendo como base uma estratégia de valorização de sub-produtos marinhos, nomeadamente pele e dentes de tubarão.Os autores agradecem o apoio financeiro recebido da União Europeia através do Programa INTERREG—POCTEP, no âmbito dos Projetos 0687_NOVOMAR_1_P e 0245_IBEROS_1_E, através do Programa de cooperação transnacional Espaço Atlântico, no âmbito do Projeto MARMED (2011-1/164) e através do 7º Programa-Quadro de Investigação e Desenvolvimento Tecnológico (FP7), através do Projeto POLARIS (REGPOT-CT2012-316331). Os autores gostariam de agradecer também ao Centro Tecnológico del Mar (CETMAR, Vigo, Espanha) e COPEMAR SA (Espanha) pelo fornecimento dos subprodutos de tubarão. G.S.D agradece ao Programa Norte2020 (Portugal2020) pela bolsa de doutoramento (NORTE-08-5369-F SE-000044) e R.P. agradece à Fundação para a Ciência e a Tecnologia pelo contrato IF/00347/2015

Gendering international student migration: an Indian case-study

Despite the mainstreaming of gender perspectives into migration research, very few attempts have been made to gender international student migration. This paper poses three questions about Indian students who study abroad. Are there gender differences in their motivations? How do they negotiate their gendered everyday lives when abroad? Is the return to India shaped by gender relations? An online survey of Indian study-abroad students (n = 157), and in-depth interviews with Indian students in Toronto (n = 22), returned students in New Delhi (n = 21), and with parents of students abroad (n = 22) help to provide answers. Conceptually, the paper draws on a ‘gendered geographies of power’ framework and on student migration as an embodied process subject to ‘matrices of (un)intelligibility’. We find minimal gender-related differences in motivations to study abroad, except that male students are drawn from a wider social background. However, whilst abroad, both male and female Indian students face challenges in performing their gendered identities. The Indian patrifocal family puts greater pressure on males to return; females face greater challenges upon return

Modelling search for people in 900 scenes: A combined source model of eye guidance

How predictable are human eye movements during search in real world scenes? We recorded 14 observers’ eye movements as they performed a search task (person detection) in 912 outdoor scenes. Observers were highly consistent in the regions fixated during search, even when the target was absent from the scene. These eye movements were used to evaluate computational models of search guidance from three sources: Saliency, target features, and scene context. Each of these models independently outperformed a cross-image control in predicting human fixations. Models that combined sources of guidance ultimately predicted 94% of human agreement, with the scene context component providing the most explanatory power. None of the models, however, could reach the precision and fidelity of an attentional map defined by human fixations. This work puts forth a benchmark for computational models of search in real world scenes. Further improvements in modelling should capture mechanisms underlying the selectivity of observers’ fixations during search.National Eye Institute (Integrative Training Program in Vision grant T32 EY013935)Massachusetts Institute of Technology (Singleton Graduate Research Fellowship)National Science Foundation (U.S.) (Graduate Research Fellowship)National Science Foundation (U.S.) (CAREER Award (0546262))National Science Foundation (U.S.) (NSF contract (0705677))National Science Foundation (U.S.) (Career Award (0747120)

Optimizing the Activity of Nanoneedle Structured WO3 Photoanodes for Solar Water Splitting: Direct Synthesis via Chemical Vapor Deposition

Solar water splitting is a promising solution for the renewable production of hydrogen as an energy vector. To date, complex or patterned photoelectrodes have shown the highest water splitting efficiencies, but lack scalable routes for commercial scale-up. In this article, we report a direct and scalable chemical vapor deposition (CVD) route at atmospheric pressure, for a single step fabrication of complex nanoneedle structured WO3 photoanodes. Using a systematic approach, the nanostructure was engineered to find the conditions that result in optimal water splitting. The nanostructured materials adopted a monoclinic γ-WO3 structure and were highly oriented in the (002) plane, with the nanoneedle structures stacking perpendicular to the FTO substrate. The WO3 photoanode that showed the highest water splitting activity was composed of a ∼300 nm seed layer of flat WO3 with a ∼5 μm thick top layer of WO3 nanoneedles. At 1.23 VRHE, this material showed incident photon-to-current efficiencies in the range ∼35–45% in the UV region (250–375 nm) and an overall solar predicted photocurrent of 1.24 mA·cm–2 (∼25% of the theoretical maximum for WO3). When coupled in tandem with a photovoltaic device containing a methylammonium lead iodide perovskite, a solar-to-hydrogen efficiency of ca. 1% for a complete unassisted water splitting device is predicted